Megacolon
Megacolon from a Rescue point of view:
Megacolon is a topic that we would like to devote a fair amount of time and attention to since it’s still not being widely recognized by even rabbit savvy exotic vets. Since Megacolon is a genetic disorder, there are specific indicators of the potential of certain rabbits being afflicted. Largely, English spots, but in general rabbits with a lack of color in their patterns. Megacolon cannot be diagnosed by a fecal test or bloodwork and may be detected by looking at enlarged colon, intestines in x-rays.
To learn the basics of Megacolon there are some good resources here:
YouTube: Paula Watkins Triangle Rabbits
Megacolon article by Long Island Rabbit Rescue, (PDF downloadable version)
Honestly speaking, the best way to learn about megacolon is if you have an MC bunny and you are forced to learn how to feed and care for one. You may become more well versed on the topic and then need to work individually with your vet. You may even meet resistance from more than one vet about whether or not megacolon exists or is treatable. They will usually treat the symptoms as they do GI stasis, slow gut, etc.
I came to learn about megacolon over due time & with diligence. Some of the key ways to care for a bunny with pre-megacolon (for lack of a better word) is through diet & a strict routine. Keep a food journal/log and record all observations based on reactions to foods, specific greens & if your bunny progresses to a full blown case of megacolon, work with your vet on a medicine protocol, in conjunction with a strict diet.
More to come on this very important and under reported topic.